A major goal of our research is to understand the complex process of extracellular matrix (ECM) secretion and assembly, with a particular focus on ECM proteins important to the cardiovascular system. We are interested in how ECM macromolecules assemble into complex polymers in the extracellular space, and how ECM influences the phenotype of cells, including the role of ECM in initiating differentiation and in maintaining appropriate gene expression in the differentiated phenotype. Our research involves identifying biologically active signals within ECM molecules that act directly on cell function. These studies include an interest in receptors for extracellular matrix

The laboratory also has had a long-standing interest in vascular development and disease, particularly in understanding the development of the vessel wall and the recruitment and differentiation of smooth muscle cells. DNA and RNA sequencing technologies are used to identify genes differentially expressed in developing vessels and in vascular disease models. Using knockout and transgenic mice, we study how the overexpression or underexpression of key vascular wall proteins influences the development and function of the cardiovascular system. Single cell sequencing, RNASeq, in situ hybridization, and proteomic approaches are used to characterize vascular alteration associated with each animal phenotype, and physiological studies (vascular compliance, vascular reactivity, blood pressure, etc.) are used to document altered vascular function. We are also interested in human inherited diseases involving proteins of the elastic fiber, including supravalvar aortic stenosis (linked to mutations in the elastin gene), Marfan Syndrome (associated with mutations in fibrillin), aneurysms, and pulmonary and systemic hypertension.
Robert Mecham, Ph.D.
Alumni Endowed Prof. of Cell Biology &
Professor of Medicine, Pediatrics, and Bio- engineering

Phone Numbers:
(314) 362-2254 Office
(314) 362-2211 Lab
(314) 362-2212 Lab

Postal Address
Dept. Cell Biology
Campus Box 8228
660 South Euclid Ave.
St. Louis, MO 63110